1. Metabolismo energético central, alteraciones en expresión y actividad enzimática en respuesta a hipoxia
2. Sistema antioxidante y respuestas a estresores ambientales,
3. Efectos de contaminantes tóxicos en organismos acuáticos.

• Respuestas metabólicas y de sistemas antioxidantes ante el estrés ambiental y por contaminantes en crustáceos marinos

Publicaciones seleccionadas, últimos 5 años 2019-2023

1. Romero-Reyes A., Hernandez-Leon S.G., Leyva-Carrillo L., Yepiz-Plascencia G.M., Reynolds, M.P., Paul, M.J., Heuer, S. and Valenzuela-Soto, E.M. 2023. An efficient triose phosphate synthesis and distribution in wheat provides tolerance to higher field temperatures. Biochemical Journal 480: 1365–1377. https://doi.org/10.1042/BCJ20230117
2. Estrada-Cardenas P., Peregrino-Uriarte A.B., Gómez-Jiménez S., Valenzuela-Soto E.M., Leyva Carrillo L., Yepiz Plascencia G. 2023. Responses and modulation of the white shrimp Litopenaeus vannamei glutathione peroxidases 2 and 4 during hypoxia, reoxygenation and GPx4 knock-down. Biochimie214:157-164. https://doi.org/10.1016/j.biochi.2023.07.006
3. Camacho Jiménez L., Peregrino Uriarte A.B., Leyva Carrillo L., Gómez Jiménez S., Thies A., Tresguerres M., Yepiz Plascencia G. 2023. Effects of severe hypoxia and glyceraldehyde-3- phosphate dehydrogenase (GAPDH) knock- down on its gene expression, activity, subcellular localization, and apoptosis in gills of the shrimp Penaeus vannamei. Marine and Freshwater Behaviour and Physiology. 56(3–4):91–110 https://doi.org/10.1080/10236244.2023.2216346
4. Cruz-Moreno P., Valenzuela-Soto E, Peregrino-Uriarte A.B., Leyva-Carrillo L., Soñanez-Organis J.G., Yepiz-Plascencia G. 2023. The pyruvate kinase of the whiteleg shrimp Litopenaeus vannamei: Gene structure and responses to short term hypoxia. Comp Biochem Physiol A Mol Integr Physiol. 283: 111468, https://doi.org/10.1016/j.cbpa.2023.111468
5. Hernández-Aguirre L.E., Peregrino-Uriarte A-B., Duarte Gutiérrez J.L., Leyva-Carrillo L., Ezquerra-Brauer J.M., Valenzuela-Soto E.M., Yepiz-Plascencia G. 2023. Shrimp Glucose-6-Phosphatase 2 (G6Pase 2): a second isoform of G6Pase in the Pacific white shrimp and regulation of G6Pase 1 and 2 isoforms via HIF-1 during hypoxia and reoxygenation in juveniles. J Bioenergetics and Biomembranes https://doi.org/10.1007/s10863-023-09960-z
6. González-Ruiz R., Leyva-Carrillo L., Peregrino-Uriarte A.B., Yepiz-Plascencia G. 2022. The combination of hypoxia and high temperature affects heat shock, anaerobic metabolism, and pentose phosphate pathway key components responses in the white shrimp (Litopenaeus vannamei). Cell Stress Chaperones. doi: 10.1007/s12192-022-01265-1.
7. Flores-Sauceda M., Camacho-Jiménez L., Peregrino-Uriarte A.B., Leyva-Carrillo L., Arvizu-Flores A., Yepiz-Plascencia G. 2022. The bifunctional 6-phosphofructokinase-2/frustose-2,6-bisphoshatase from the shrimp Litopenaus vannamei: Molecular characterization and down-regulation of expression in response to severe hypoxia. Comp Biochem Physiol, Part A. 263: 111095 https://doi.org/10.1016/j.cbpa.2021.111095
8. Nuñez-Hernández D., Camacho-Jiménez L., Leyva-Carrillo L., Peregrino-Uriarte A.B., Valenzuela-Soto E.M., Gómez-Jiménez S., Gonzalez-Rios H., Yepiz- Plascencia G. 2021. Expression of p53 isoforms in response to two levels of hypoxia and effects of p53 knock-down in glyceraldehyde-3-phpsphate dehydrogenase in the white shrimp Litopenaeus vannamei. Aq Res. 00:1-11. DOI: 10.1111/are.15083
9. Estrada-Cárdenas P., Cruz-Moreno D., González-Ruiz R., Peregrino-Uriarte A., Leyva-Carrillo L., Camacho-Jiménez L., Quintero-Reyes I., Yepiz-Plascencia G. 2021. Combined hypoxia and high temperature affect differentially the response of antioxidant enzymes, glutathione and hydrogen peroxide in the White shrimp Litopenaeus vannamei. Comp Biochem Physiol, Part A. 254: 110909. doi.org/10.1016/j.cbpa.2021.110909
10. Duarte-Gutierrez J., Leyva-Carrillo L., Martinez-Tellez M.A., Mendez-Estrada R. O.; Felix-Portillo M., Yepiz-Plascencia G. 2020. Cloning, expression, purification and biochemical characterization of recombinant metallothionein from the white shrimp Litopenaeus vannamei. Prot Exp Pur. 166: 105511
11. Camacho-Jiménez L., Leyva-Carrillo L. Peregrino-Uriarte A.B., Duarte-Gutierrez J., Tresguerres M., Yepiz-Plascencia G. 2019. Regulation of glyceraldehyde-3-phosphate dehydrogenase by hypoxia inducible factor 1 in the white shrimp Litopenaeus vannamei during hypoxia and reoxygenation. Comp Biochem Physiol A-Mol Int Physiol. 235:56-65.
12. Leyva-Carrillo L., Hernandez-Palomares M., Valenzuela-Soto E.M., Figueroa-Soto C., Yepiz-Plascencia G. 2019. Purification and partial biochemical characterization of recombinant lactate dehydrogenase 1 (LDH-1) of the white shrimp Litopenaeus vannamei Prot Exp Pur. 164:105461 https://doi.org/10.1016/j.pep.2019.105461

• Modulación de glucólisis y gluconeogénesis durante la hipoxia en camarón blanco.
• Resiliencia del camarón Penaeus vannamaei frente a la contaminación de origen antropogénico: respuesta de genes del metabolismo de xenobióticos y sistemas antioxidantes durante la exposición a hidrocarburos aromáticos policíclicos (PAHs)